Human autologous iPSC–derived dopaminergic progenitors restore motor function in Parkinson’s disease models

Parkinson’s disease (PD) is a neurodegenerative disorder associated with loss of striatal dopamine, secondary to degeneration of midbrain dopamine (mDA) neurons in the substantia nigra, rendering cell transplantation a promising therapeutic strategy. To establish human induced pluripotent stem cell–...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Song, Bin, Cha, Young, Ko, Sanghyeok, Jeon, Jeha, Lee, Nayeon, Seo, Hyemyung, Park, Kyung-Joon, Lee, In-Hee, Lopes, Claudia, Feitosa, Melissa, Luna, María José, Jung, Jin Hyuk, Kim, Jisun, Hwang, Dabin, Cohen, Bruce M., Teicher, Martin H., Leblanc, Pierre, Carter, Bob S., Kordower, Jeffrey H., Bolshakov, Vadim Y., Kong, Sek Won, Schweitzer, Jeffrey S., Kim, Kwang-Soo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994130/
https://ncbi.nlm.nih.gov/pubmed/31714896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130767
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