Characterization and Optimization of Multiplexed Quantitative Analyses Using High-Field Asymmetric-Waveform Ion Mobility Mass Spectrometry

Multiplexed, isobaric tagging methods are powerful techniques to increase throughput, precision, and accuracy in quantitative proteomics. The dynamic range and accuracy of quantitation, however, can be limited by coisolation of tag-containing peptides that release reporter ions and conflate quantita...

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Publié dans:Anal Chem
Auteurs principaux: Schweppe, Devin K., Prasad, Satendra, Belford, Michael W., Navarrete-Perea, José, Bailey, Derek J., Huguet, Romain, Jedrychowski, Mark P., Rad, Ramin, McAlister, Graeme, Abbatiello, Susan E., Woulters, Eloy R., Zabrouskov, Vlad, Dunyach, Jean-Jacques, Paulo, João A., Gygi, Steven P.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993951/
https://ncbi.nlm.nih.gov/pubmed/30672687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b05399
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