Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis

Melatonin, a neuroendocrine hormone synthesized by the pineal gland and cholangiocytes, decreases biliary hyperplasia and liver fibrosis during cholestasis-induced biliary injury via melatonin-dependent autocrine signaling through increased biliary arylalkylamine N-acetyltransferase (AANAT) expressi...

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Publicado no:Biochim Biophys Acta Mol Basis Dis
Main Authors: Chen, Lixian, Zhou, Tianhao, Wu, Nan, O'Brien, April, Venter, Julie, Ceci, Ludovica, Kyritsi, Konstantina, Onori, Paolo, Gaudio, Eugenio, Sybenga, Amelia, Xie, Linglin, Wu, Chaodong, Fabris, Luca, Invernizzi, Pietro, Zawieja, David, Liangpunsakul, Suthat, Meng, Fanyin, Francis, Heather, Alpini, Gianfranco, Huang, Qiaobing, Glaser, Shannon
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993622/
https://ncbi.nlm.nih.gov/pubmed/30890428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2019.03.002
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