Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis

BACKGROUND AND AIMS: Serotonin (5HT) is a neuroendocrine hormone synthetized in the central nervous system (CNS) as well as enterochromaffin cells of the gastrointestinal tract. Tryptophan hydroxylase (TPH1) and monoamine oxidase (MAO-A) are the key enzymes for the synthesis and catabolism of 5HT, r...

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Published in:Hepatology
Main Authors: Kyritsi, Konstantina, Chen, Lixian, O’Brien, April, Francis, Heather, Hein, Travis W., Venter, Julie, Wu, Nan, Ceci, Ludovica, Zhou, Tianhao, Zawieja, David, Gashev, Anatoliy A., Meng, Fanyin, Invernizzi, Pietro, Fabris, Luca, Wu, Chaodong, Skill, Nicholas J., Saxena, Romil, Liangpunsakul, Suthat, Alpini, Gianfranco, Glaser, Shannon S.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993623/
https://ncbi.nlm.nih.gov/pubmed/31344280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30880
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