Downregulation of p16 Decreases Biliary Damage and Liver Fibrosis in the Mdr2(−/−) Mouse Model of Primary Sclerosing Cholangitis

Biliary senescence and hepatic fibrosis are hallmarks of cholangiopathies including primary sclerosing cholangitis (PSC). Senescent cholangiocytes display senescence-associated secretory phenotypes [SASPs, e.g., transforming growth factor-β1 (TGF-β1)] that further increase biliary senescence (by an...

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Détails bibliographiques
Publié dans:Gene Expr
Auteurs principaux: Kyritsi, Konstantina, Francis, Heather, Zhou, Tianhao, Ceci, Ludovica, Wu, Nan, Yang, Zhihong, Meng, Fanyin, Chen, Lixian, Baiocchi, Leonardo, Kundu, Debjyoti, Kennedy, Lindsey, Liangpunsakul, Suthat, Wu, Chaodong, Glaser, Shannon, Alpini, Gianfranco
Format: Artigo
Langue:Inglês
Publié: Cognizant Communication Corporation 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650011/
https://ncbi.nlm.nih.gov/pubmed/32393417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/105221620X15889714507961
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