Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2(−/−) mice

Primary sclerosing cholangitis (PSC) is characterized by increased mast cell (MC) infiltration, biliary damage and hepatic fibrosis. Cholangiocytes secrete stem cell factor (SCF), which is a chemoattractant for c-kit expressed on MCs. We aimed to determine if blocking SCF inhibits MC migration, bili...

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Publicado en:Biochim Biophys Acta Mol Basis Dis
Autores principales: Meadows, Vik, Kennedy, Lindsey, Hargrove, Laura, Demieville, Jennifer, Meng, Fanyin, Virani, Shohaib, Reinhart, Evan, Kyritsi, Konstantina, Invernizzi, Pietro, Yang, Zhihong, Wu, Nan, Liangpunsakul, Suthat, Alpini, Gianfranco, Francis, Heather
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6878979/
https://ncbi.nlm.nih.gov/pubmed/31521820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2019.165557
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