Ursodeoxycholate inhibits mast cell activation and reverses biliary injury and fibrosis in Mdr2(−/−) mice and human primary sclerosing cholangitis

BACKGROUND AND AIM: Ursodeoxycholic acid (UDCA) is used to treat biliary disorders; and, bile acids alter mast cell (MC) histamine release. MCs infiltrate Mdr2(−/−) mice liver (model of Primary Sclerosing Cholangitis (PSC)). MC-derived histamine increases inflammation, hepatic stellate cell (HSC) ac...

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Bibliographic Details
Published in:Lab Invest
Main Authors: Meng, Fanyin, Kennedy, Lindsey, Hargrove, Laura, Demieville, Jennifer, Jones, Hannah, Madeka, Taronish, Karstens, Allen, Chappell, Kevin, Alpini, Gianfranco, Sybenga, Amelia, Invernizzi, Pietro, Bernuzzi, Francesca, DeMorrow, Sharon, Francis, Heather
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214746/
https://ncbi.nlm.nih.gov/pubmed/30143751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-018-0101-0
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