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BDL-induced biliary hyperplasia, hepatic injury and fibrosis are reduced in mast cell deficient Kit(w-sh) mice

Activated mast cells (MCs) release histamine (HA) and MCs infiltrate the liver following bile duct ligation (BDL) increasing intrahepatic bile duct mass (IBDM) and fibrosis. We evaluated the effects of BDL in MC deficient mice. Methods: WT and Kit(W-sh) mice were subjected to sham or BDL for up to 7...

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發表在:Hepatology
Main Authors: Hargrove, Laura, Kennedy, Lindsey, Demieville, Jennifer, Jones, Hannah, Meng, Fanyin, DeMorrow, Sharon, Karstens, Walker, Madeka, Taronish, Greene, John, Francis, Heather
格式: Artigo
語言:Inglês
出版: 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444972/
https://ncbi.nlm.nih.gov/pubmed/28120369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29079
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