Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis

Biliary hyperplasia and liver fibrosis are common features in cholestatic liver disease. Melatonin is synthesized by the pineal gland as well as the liver. Melatonin inhibits biliary hyperplasia of bile duct-ligated (BDL) rats. Since melatonin synthesis (by the enzyme serotonin N-acetyltransferase,...

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Hlavní autoři: Han, Yuyan, Onori, Paolo, Meng, Fanyin, DeMorrow, Sharon, Venter, Julie, Francis, Heather, Franchitto, Antonio, Ray, Debolina, Kennedy, Lindsey, Greene, John, Renzi, Anastasia, Mancinelli, Romina, Gaudio, Eugenio, Glaser, Shannon, Alpini, Gianfranco
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2014
Témata:
Liver and Biliary Tract
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216989/
https://ncbi.nlm.nih.gov/pubmed/25214401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00288.2014
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