Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis

Biliary hyperplasia and liver fibrosis are common features in cholestatic liver disease. Melatonin is synthesized by the pineal gland as well as the liver. Melatonin inhibits biliary hyperplasia of bile duct-ligated (BDL) rats. Since melatonin synthesis (by the enzyme serotonin N-acetyltransferase,...

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Detalhes bibliográficos
Main Authors: Han, Yuyan, Onori, Paolo, Meng, Fanyin, DeMorrow, Sharon, Venter, Julie, Francis, Heather, Franchitto, Antonio, Ray, Debolina, Kennedy, Lindsey, Greene, John, Renzi, Anastasia, Mancinelli, Romina, Gaudio, Eugenio, Glaser, Shannon, Alpini, Gianfranco
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216989/
https://ncbi.nlm.nih.gov/pubmed/25214401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00288.2014
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