Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors

In bile duct-ligated (BDL) rats, large cholangiocytes proliferate by activation of cAMP-dependent signaling. Melatonin, which is secreted from pineal gland as well as extrapineal tissues, regulates cell mitosis by interacting with melatonin receptors (MT1 and MT2) modulating cAMP and clock genes. In...

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Autori principali: Renzi, Anastasia, Glaser, Shannon, DeMorrow, Sharon, Mancinelli, Romina, Meng, Fanyin, Franchitto, Antonio, Venter, Julie, White, Mellanie, Francis, Heather, Han, Yuyan, Alvaro, Domenico, Gaudio, Eugenio, Carpino, Guido, Ueno, Yoshiyuki, Onori, Paolo, Alpini, Gianfranco
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2011
Soggetti:
Liver and Biliary Tract
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191552/
https://ncbi.nlm.nih.gov/pubmed/21757639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00206.2011
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