Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes

BACKGROUND & AIMS: Secretin stimulates ductal secretion by interacting with secretin receptor (SR) activating cAMP⇒CFTR⇒Cl(−)/HCO(3)(−) AE2 signaling that is elevated by biliary hyperplasia. Cholangiocytes secrete several neuroendocrine factors regulating biliary functions by autocrine mechanism...

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Detalhes bibliográficos
Main Authors: Renzi, Anastasia, DeMorrow, Sharon, Onori, Paolo, Carpino, Guido, Mancinelli, Romina, Meng, Fanyin, Venter, Julie, White, Mellanie, Franchitto, Antonio, Francis, Heather, Han, Yuyan, Ueno, Yoshiyuki, Dusio, Giuseppina, Jensen, Kendal J, Greene, John J, Glaser, Shannon, Gaudio, Eugenio, Alpini, Gianfranco
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566412/
https://ncbi.nlm.nih.gov/pubmed/23080076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26105
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