Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2(−/−) mice and human cholangiocarcinoma tumorigenesis

BACKGROUND: Primary Sclerosing Cholangitis (PSC) patients are at risk of developing cholangiocarcinoma (CCA). We have shown that: (i) histamine (HA) increases biliary hyperplasia via H1/H2 histamine receptors (HRs) and (ii) HA levels increase and mast cells (MCs) infiltrate during PSC and CCA. We ai...

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Détails bibliographiques
Publié dans:Hepatology
Auteurs principaux: Kennedy, Lindsey, Hargrove, Laura, Demieville, Jennifer, Karstens, Allen, Jones, Hannah, DeMorrow, Sharon, Meng, Fanyin, Invernizzi, Pietro, Bernuzzi, Francesca, Alpini, Gianfranco, Smith, Steven, Akers, Austin, Meadows, Victoria, Francis, Heather
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6165706/
https://ncbi.nlm.nih.gov/pubmed/29601088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29898
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