H3 Histamine Receptor–Mediated Activation of Protein Kinase Cα Inhibits the Growth of Cholangiocarcinoma In vitro and In vivo

Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The d-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth. We evaluated the role of HRH3 in the regulation of cholangiocarcin...

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Autors principals: Francis, Heather, Onori, Paolo, Gaudio, Eugenio, Franchitto, Antonio, DeMorrow, Sharon, Venter, Julie, Kopriva, Shelley, Carpino, Guido, Mancinelli, Romina, White, Mellanie, Meng, Fanyin, Vetuschi, Antonella, Sferra, Roberta, Alpini, Gianfranco
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788765/
https://ncbi.nlm.nih.gov/pubmed/19825989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0261
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