The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway

Cholangiocarcinomas are cancers that have poor prognosis and limited treatment options. The noncanonical Wnt pathway is mediated predominantly by Wnt 5a, which activates a Ca(2+)-dependent pathway involving protein kinase C, or a Ca(2+)-independent pathway involving the orphan receptor Ror2 and subs...

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Detalhes bibliográficos
Main Authors: DeMorrow, Sharon, Francis, Heather, Gaudio, Eugenio, Venter, Julie, Franchitto, Antonio, Kopriva, Shelley, Onori, Paolo, Mancinelli, Romina, Frampton, Gabriel, Coufal, Monique, Mitchell, Brett, Vaculin, Bradley, Alpini, Gianfranco
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604798/
https://ncbi.nlm.nih.gov/pubmed/18832445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90455.2008
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