Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation

New antimalarial drugs are needed. The benzoxaborole AN13762 showed excellent activity against cultured Plasmodium falciparum, against fresh Ugandan P. falciparum isolates, and in murine malaria models. To gain mechanistic insights, we selected in vitro for P. falciparum isolates resistant to AN1376...

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Xehetasun bibliografikoak
Argitaratua izan da:mBio
Egile Nagusiak: Sindhe, Kirthana M. V., Wu, Wesley, Legac, Jenny, Zhang, Yong-Kang, Easom, Eric E., Cooper, Roland A., Plattner, Jacob J., Freund, Yvonne R., DeRisi, Joseph L., Rosenthal, Philip J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989105/
https://ncbi.nlm.nih.gov/pubmed/31992618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02640-19
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