Tetracyclines Specifically Target the Apicoplast of the Malaria Parasite Plasmodium falciparum

Tetracyclines are effective but slow-acting antimalarial drugs whose mechanism of action remains uncertain. To characterize the antimalarial mechanism of tetracyclines, we evaluated their stage-specific activities, impacts on parasite transcription, and effects on two predicted organelle targets, th...

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Bibliografiska uppgifter
Huvudupphovsmän: Dahl, Erica L., Shock, Jennifer L., Shenai, Bhaskar R., Gut, Jiri, DeRisi, Joseph L., Rosenthal, Philip J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2006
Ämnen:
Mechanisms of Action: Physiological Effects
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563505/
https://ncbi.nlm.nih.gov/pubmed/16940111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00394-06
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