Blocking Plasmodium falciparum Development via Dual Inhibition of Hemoglobin Degradation and the Ubiquitin Proteasome System by MG132

Among key potential drug target proteolytic systems in the malaria parasite Plasmodium falciparum are falcipains, a family of hemoglobin-degrading cysteine proteases, and the ubiquitin proteasomal system (UPS), which has fundamental importance in cellular protein turnover. Inhibition of falcipains b...

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Dades bibliogràfiques
Autors principals: Prasad, Rajesh, Atul, Kolla, Venkata Karunakar, Legac, Jennifer, Singhal, Neha, Navale, Rahul, Rosenthal, Philip J., Sijwali, Puran Singh
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759421/
https://ncbi.nlm.nih.gov/pubmed/24023882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073530
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