Blocking Plasmodium falciparum Development via Dual Inhibition of Hemoglobin Degradation and the Ubiquitin Proteasome System by MG132

Among key potential drug target proteolytic systems in the malaria parasite Plasmodium falciparum are falcipains, a family of hemoglobin-degrading cysteine proteases, and the ubiquitin proteasomal system (UPS), which has fundamental importance in cellular protein turnover. Inhibition of falcipains b...

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Autori principali: Prasad, Rajesh, Atul, Kolla, Venkata Karunakar, Legac, Jennifer, Singhal, Neha, Navale, Rahul, Rosenthal, Philip J., Sijwali, Puran Singh
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759421/
https://ncbi.nlm.nih.gov/pubmed/24023882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073530
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