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Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1

The HIV protease inhibitor lopinavir inhibits Plasmodium falciparum aspartic proteases (plasmepsins) and parasite development, and children receiving lopinavir-ritonavir experienced fewer episodes of malaria than those receiving other antiretroviral regimens. Resistance to lopinavir was selected in...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Sonoiki, Ebere, Nsanzabana, Christian, Legac, Jennifer, Sindhe, Kirthana M. V., DeRisi, Joseph, Rosenthal, Philip J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192118/
https://ncbi.nlm.nih.gov/pubmed/27821443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01949-16
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