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Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites

Polymorphisms in the Plasmodium falciparum multidrug resistance 1 (pfmdr1) gene impact sensitivity to multiple antimalarials. In Africa, polymorphisms at N86Y and D1246Y are common and have various impacts on sensitivity to different drugs. To gain insight into the fitness consequences of these poly...

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Detalhes bibliográficos
Main Authors: Ochong, Edwin, Tumwebaze, Patrick K., Byaruhanga, Oswald, Greenhouse, Bryan, Rosenthal, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754360/
https://ncbi.nlm.nih.gov/pubmed/23796921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00161-13
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