Plasmodium falciparum pfmdr1 Amplification, Mefloquine Resistance, and Parasite Fitness

Mefloquine is widely used in combination with artemisinin derivatives for the treatment of falciparum malaria. Mefloquine resistance in Plasmodium falciparum has been related to increased copy numbers of multidrug-resistant gene 1 (pfmdr1). We studied the ex vivo dynamics of pfmdr1 gene amplificatio...

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Bibliographic Details
Main Authors: Preechapornkul, Piyanuch, Imwong, Mallika, Chotivanich, Kesinee, Pongtavornpinyo, Wirichada, Dondorp, Arjen M., Day, Nicholas P. J., White, Nicholas J., Pukrittayakamee, Sasithon
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663078/
https://ncbi.nlm.nih.gov/pubmed/19164150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00241-08
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