Plasmodium falciparum pfmdr1 Amplification, Mefloquine Resistance, and Parasite Fitness

Mefloquine is widely used in combination with artemisinin derivatives for the treatment of falciparum malaria. Mefloquine resistance in Plasmodium falciparum has been related to increased copy numbers of multidrug-resistant gene 1 (pfmdr1). We studied the ex vivo dynamics of pfmdr1 gene amplificatio...

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Библиографические подробности
Главные авторы: Preechapornkul, Piyanuch, Imwong, Mallika, Chotivanich, Kesinee, Pongtavornpinyo, Wirichada, Dondorp, Arjen M., Day, Nicholas P. J., White, Nicholas J., Pukrittayakamee, Sasithon
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2009
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663078/
https://ncbi.nlm.nih.gov/pubmed/19164150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00241-08
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