Gene Amplification of the Multidrug Resistance 1 Gene of Plasmodium vivax Isolates from Thailand, Laos, and Myanmar

Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of ge...

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Hauptverfasser: Imwong, Mallika, Pukrittayakamee, Sasithon, Pongtavornpinyo, Wirichada, Nakeesathit, Supatchara, Nair, Shalini, Newton, Paul, Nosten, Francois, Anderson, Timothy J. C., Dondorp, Arjen, Day, Nicholas P. J., White, Nicholas J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443893/
https://ncbi.nlm.nih.gov/pubmed/18443118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01459-07
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