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Expression of human lambda expands the repertoire of OmniChickens

Most of the approved monoclonal antibodies used in the clinic were initially discovered in mice. However, many targets of therapeutic interest are highly conserved proteins that do not elicit a robust immune response in mice. There is a need for non-mammalian antibody discovery platforms which would...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Ching, Kathryn H., Berg, Kimberley, Morales, Jacqueline, Pedersen, Darlene, Harriman, William D., Abdiche, Yasmina N., Leighton, Philip A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988971/
https://ncbi.nlm.nih.gov/pubmed/31995598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228164
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