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Expression of human lambda expands the repertoire of OmniChickens

Most of the approved monoclonal antibodies used in the clinic were initially discovered in mice. However, many targets of therapeutic interest are highly conserved proteins that do not elicit a robust immune response in mice. There is a need for non-mammalian antibody discovery platforms which would...

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Pubblicato in:PLoS One
Autori principali: Ching, Kathryn H., Berg, Kimberley, Morales, Jacqueline, Pedersen, Darlene, Harriman, William D., Abdiche, Yasmina N., Leighton, Philip A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988971/
https://ncbi.nlm.nih.gov/pubmed/31995598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228164
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