Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets

Transgenic animal platforms for the discovery of human monoclonal antibodies have been developed in mice, rats, rabbits and cows. The immune response to human proteins is limited in these animals by their tolerance to mammalian-conserved epitopes. To expand the range of epitopes that are accessible,...

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Библиографические подробности
Опубликовано в: :MAbs
Главные авторы: Ching, Kathryn H., Collarini, Ellen J., Abdiche, Yasmina N., Bedinger, Daniel, Pedersen, Darlene, Izquierdo, Shelley, Harriman, Rian, Zhu, Lei, Etches, Robert J., van de Lavoir, Marie-Cecile, Harriman, William D., Leighton, Philip A.
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2017
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Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800366/
https://ncbi.nlm.nih.gov/pubmed/29035625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1386825
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