Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets

Transgenic animal platforms for the discovery of human monoclonal antibodies have been developed in mice, rats, rabbits and cows. The immune response to human proteins is limited in these animals by their tolerance to mammalian-conserved epitopes. To expand the range of epitopes that are accessible,...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Ching, Kathryn H., Collarini, Ellen J., Abdiche, Yasmina N., Bedinger, Daniel, Pedersen, Darlene, Izquierdo, Shelley, Harriman, Rian, Zhu, Lei, Etches, Robert J., van de Lavoir, Marie-Cecile, Harriman, William D., Leighton, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800366/
https://ncbi.nlm.nih.gov/pubmed/29035625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1386825
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