Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets

Transgenic animal platforms for the discovery of human monoclonal antibodies have been developed in mice, rats, rabbits and cows. The immune response to human proteins is limited in these animals by their tolerance to mammalian-conserved epitopes. To expand the range of epitopes that are accessible,...

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Veröffentlicht in:MAbs
Hauptverfasser: Ching, Kathryn H., Collarini, Ellen J., Abdiche, Yasmina N., Bedinger, Daniel, Pedersen, Darlene, Izquierdo, Shelley, Harriman, Rian, Zhu, Lei, Etches, Robert J., van de Lavoir, Marie-Cecile, Harriman, William D., Leighton, Philip A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800366/
https://ncbi.nlm.nih.gov/pubmed/29035625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1386825
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