Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ)

PKC (protein kinase C) θ is predominantly expressed in T-cells and is critically involved in immunity. Design of PKCθ-selective molecules to manage autoimmune disorders by targeting its activator-binding C1 domain requires the knowledge of its structure and the activator-binding residues. The C1 dom...

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Vydáno v:Biochem J
Hlavní autoři: Rahman, Ghazi M., Shanker, Sreejesh, Lewin, Nancy E., Kedei, Noemi, Hill, Colin S., Prasad, B. V. Venkataram, Blumberg, Peter M., Das, Joydip
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988732/
https://ncbi.nlm.nih.gov/pubmed/23289588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121307
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