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A latent variable model for improving inference in trials assessing the effect of dose on toxicity and composite efficacy endpoints

It is often of interest to explore how dose affects the toxicity and efficacy properties of a novel treatment. In oncology, efficacy is often assessed through response, which is defined by a patient having no new tumour lesions and their tumour size shrinking by 30%. Usually response and toxicity ar...

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Bibliografische gegevens
Gepubliceerd in:Stat Methods Med Res
Hoofdauteurs: Wason, James M. S., Seaman, Shaun R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986906/
https://ncbi.nlm.nih.gov/pubmed/30799777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0962280219831038
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