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Improving the analysis of composite endpoints in rare disease trials
BACKGROUND: Composite endpoints are recommended in rare diseases to increase power and/or to sufficiently capture complexity. Often, they are in the form of responder indices which contain a mixture of continuous and binary components. Analyses of these outcomes typically treat them as binary, thus...
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| Pubblicato in: | Orphanet J Rare Dis |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5964664/ https://ncbi.nlm.nih.gov/pubmed/29788976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13023-018-0819-1 |
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