GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

Transcriptional repression needs to be rapidly reversible during embryonic development. This extends to the Hedgehog pathway, which primarily serves to counter GLI repression by processing GLI proteins into transcriptional activators. In investigating the mechanisms underlying GLI repression, we fin...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lex, Rachel K, Ji, Zhicheng, Falkenstein, Kristin N, Zhou, Weiqiang, Henry, Joanna L, Ji, Hongkai, Vokes, Steven A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986877/
https://ncbi.nlm.nih.gov/pubmed/31989924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50670
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