GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

Transcriptional repression needs to be rapidly reversible during embryonic development. This extends to the Hedgehog pathway, which primarily serves to counter GLI repression by processing GLI proteins into transcriptional activators. In investigating the mechanisms underlying GLI repression, we fin...

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Vydáno v:eLife
Hlavní autoři: Lex, Rachel K, Ji, Zhicheng, Falkenstein, Kristin N, Zhou, Weiqiang, Henry, Joanna L, Ji, Hongkai, Vokes, Steven A
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986877/
https://ncbi.nlm.nih.gov/pubmed/31989924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50670
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