Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis

[Image: see text] From a high-throughput screen of 42 444 known human kinases inhibitors, a pyrazolo[1,5-b]pyridazine scaffold was identified to begin optimization for the treatment of human African trypanosomiasis. Previously reported data for analogous compounds against human kinases GSK-3β, CDK-2...

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Vydáno v:J Med Chem
Hlavní autoři: Tear, Westley F., Bag, Seema, Diaz-Gonzalez, Rosario, Ceballos-Pérez, Gloria, Rojas-Barros, Domingo I., Cordon-Obras, Carlos, Pérez-Moreno, Guiomar, García-Hernández, Raquel, Martinez-Martinez, Maria Santos, Ruiz-Perez, Luis Miguel, Gamarro, Francisco, Gonzalez Pacanowska, Dolores, Caffrey, Conor R., Ferrins, Lori, Manzano, Pilar, Navarro, Miguel, Pollastri, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985937/
https://ncbi.nlm.nih.gov/pubmed/31846577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01741
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