2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy

[Image: see text] A series of 2-amino-2,3-dihydro-1H-indene-5-carboxamides were designed and synthesized as new selective discoidin domain receptor 1 (DDR1) inhibitors. One of the representative compounds, 7f, bound with DDR1 with a K(d) value of 5.9 nM and suppressed the kinase activity with an hal...

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Vydáno v:J Med Chem
Hlavní autoři: Zhu, Dongsheng, Huang, Huocong, Pinkas, Daniel M., Luo, Jinfeng, Ganguly, Debolina, Fox, Alice E., Arner, Emily, Xiang, Qiuping, Tu, Zheng-Chao, Bullock, Alex N., Brekken, Rolf A., Ding, Ke, Lu, Xiaoyun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985936/
https://ncbi.nlm.nih.gov/pubmed/31310125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00365
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