Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors

[Image: see text] Acute lung injury (ALI) is a deadly symptom for serious lung inflammation. Discoidin Domain Receptor 1 (DDR1) is a new potential target for anti-inflammatory drug discovery. A new selective tetrahydroisoquinoline-7-carboxamide based DDR1 inhibitor 7ae was discovered to tightly bind...

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Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Wang, Zhen, Zhang, Yali, Bartual, Sergio G., Luo, Jinfeng, Xu, Tingting, Du, Wenting, Xun, Qiuju, Tu, Zhengchao, Brekken, Rolf A., Ren, Xiaomei, Bullock, Alex N., Liang, Guang, Lu, Xiaoyun, Ding, Ke
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2017
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346979/
https://ncbi.nlm.nih.gov/pubmed/28337325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00497
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