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Design and Optimization of 3′-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors

[Image: see text] DDR1 is considered as a promising target for cancer therapy, and selective inhibitors against DDR1 over other kinases may be considered as promising therapeutic agents. Herein, we have identified a series of 3′-(imidazo[1,2-a]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as novel se...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Mo, Cheng, Zhang, Zhang, Li, Yupeng, Huang, Minhao, Zou, Jian, Luo, Jinfeng, Tu, Zheng-Chao, Xu, Yong, Ren, Xiaomei, Ding, Ke, Lu, Xiaoyun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2020
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7074218/
https://ncbi.nlm.nih.gov/pubmed/32184973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00495
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