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2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy
[Image: see text] A series of 2-amino-2,3-dihydro-1H-indene-5-carboxamides were designed and synthesized as new selective discoidin domain receptor 1 (DDR1) inhibitors. One of the representative compounds, 7f, bound with DDR1 with a K(d) value of 5.9 nM and suppressed the kinase activity with an hal...
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| Опубликовано в: : | J Med Chem |
|---|---|
| Главные авторы: | , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical
Society
2019
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6985936/ https://ncbi.nlm.nih.gov/pubmed/31310125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00365 |
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