A phase I trial evaluating the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime – MVA85A boost in healthy UK adults

BACKGROUND: This phase I trial evaluated the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime-MVA85A boost, previously demonstrated to be protective in animal studies, in healthy UK adults. METHODS: We enrolled 42 healthy, BCG-vaccinated adults into 4 grou...

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Veröffentlicht in:Vaccine
Hauptverfasser: Wilkie, Morven, Satti, Iman, Minhinnick, Alice, Harris, Stephanie, Riste, Michael, Ramon, Raquel Lopez, Sheehan, Sharon, Thomas, Zita-Rose Manjaly, Wright, Daniel, Stockdale, Lisa, Hamidi, Ali, O'Shea, Matthew K., Dwivedi, Kritica, Behrens, Hannah Michaela, Davenne, Tamara, Morton, Joshua, Vermaak, Samantha, Lawrie, Alison, Moss, Paul, McShane, Helen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985898/
https://ncbi.nlm.nih.gov/pubmed/31735500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2019.10.102
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