WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia

K(+) deficiency stimulates renal salt reuptake via the Na(+)-Cl(−) cotransporter (NCC) of the distal convoluted tubule (DCT), thereby reducing K(+) losses in downstream nephron segments while increasing NaCl retention and blood pressure. NCC activation is mediated by a kinase cascade involving with...

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Udgivet i:Am J Physiol Renal Physiol
Main Authors: Thomson, Martin N., Cuevas, Catherina A., Bewarder, Tim M., Dittmayer, Carsten, Miller, Lauren N., Si, Jinge, Cornelius, Ryan J., Su, Xiao-Tong, Yang, Chao-Ling, McCormick, James A., Hadchouel, Juliette, Ellison, David H., Bachmann, Sebastian, Mutig, Kerim
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985824/
https://ncbi.nlm.nih.gov/pubmed/31736353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00232.2019
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