Aldosterone does not require angiotensin II to activate NCC through a WNK4–SPAK–dependent pathway

We and others have recently shown that angiotensin II can activate the sodium chloride cotransporter (NCC) through a WNK4–SPAK-dependent pathway. Because WNK4 was previously shown to be a negative regulator of NCC, it has been postulated that angiotensin II converts WNK4 to a positive regulator. Her...

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Bibliografske podrobnosti
Main Authors: van der Lubbe, Nils, Lim, Christina H., Meima, Marcel E., van Veghel, Richard, Rosenbaek, Lena Lindtoft, Mutig, Kerim, Danser, Alexander H. J., Fenton, Robert A., Zietse, Robert, Hoorn, Ewout J.
Format: Artigo
Jezik:Inglês
Izdano: Springer-Verlag 2012
Teme:
Signaling and Cell Physiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350624/
https://ncbi.nlm.nih.gov/pubmed/22549242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-012-1104-0
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