Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice

Hepatitis B virus (HBV) affects an estimated 250 million chronic carriers worldwide. Though several vaccines exist, they are ineffective for those already infected. HBV persists due to the formation of covalently closed circular DNA (cccDNA)—the viral minichromosome—in the nucleus of hepatocytes. Cu...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Amblard, Franck, Boucle, Sebastien, Bassit, Leda, Cox, Bryan, Sari, Ozkan, Tao, Sijia, Chen, Zhe, Ozturk, Tugba, Verma, Kiran, Russell, Olivia, Rat, Virgile, de Rocquigny, Hugues, Fiquet, Oriane, Boussand, Maud, Di Santo, James, Strick-Marchand, Helene, Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985704/
https://ncbi.nlm.nih.gov/pubmed/31712213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01701-19
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