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Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors
New modifications to the scaffold of previously reported HBV capsid assembly effectors such as BAY 41-4109, HAP-12 and GLS4 were explored. The anti-HBV activity in the HepAD38 system, and cytotoxicity profiles of each of the new compounds has been assessed. Among them, five new iodo- and bromo-heter...
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| Опубликовано в: : | Bioorg Med Chem Lett |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5314961/ https://ncbi.nlm.nih.gov/pubmed/28094179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.01.010 |
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