Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors

New modifications to the scaffold of previously reported HBV capsid assembly effectors such as BAY 41-4109, HAP-12 and GLS4 were explored. The anti-HBV activity in the HepAD38 system, and cytotoxicity profiles of each of the new compounds has been assessed. Among them, five new iodo- and bromo-heter...

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Publicado en:Bioorg Med Chem Lett
Autores principales: Boucle, Sebastien, Lu, Xiao, Bassit, Leda, Ozturk, Tugba, Russell, Olivia Ollinger, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314961/
https://ncbi.nlm.nih.gov/pubmed/28094179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.01.010
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