Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice

AIM: Guanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT(–/–) mice exhibit normal exercise capacity and response to ischemic heart failure. However, we hypothesized long-term conseq...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Aksentijević, Dunja, Zervou, Sevasti, Eykyn, Thomas R., McAndrew, Debra J., Wallis, Julie, Schneider, Jurgen E., Neubauer, Stefan, Lygate, Craig A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985570/
https://ncbi.nlm.nih.gov/pubmed/32038270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01535
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