Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity

Inhibition of malonyl-coenzyme A decarboxylase (MCD) shifts metabolism from fatty acid towards glucose oxidation, which has therapeutic potential for obesity and myocardial ischemic injury. However, ~ 40% of patients with MCD deficiency are diagnosed with cardiomyopathy during infancy. AIM: To clari...

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Main Authors: Aksentijević, Dunja, McAndrew, Debra J., Karlstädt, Anja, Zervou, Sevasti, Sebag-Montefiore, Liam, Cross, Rebecca, Douglas, Gillian, Regitz-Zagrosek, Vera, Lopaschuk, Gary D., Neubauer, Stefan, Lygate, Craig A.
Formato: Artigo
Idioma:Inglês
Publicado: Academic Press 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169183/
https://ncbi.nlm.nih.gov/pubmed/25066696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.07.008
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