Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine

AIMS: Creatine buffers cellular adenosine triphosphate (ATP) via the creatine kinase reaction. Creatine levels are reduced in heart failure, but their contribution to pathophysiology is unclear. Arginine:glycine amidinotransferase (AGAT) in the kidney catalyses both the first step in creatine biosyn...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Faller, Kiterie M E, Atzler, Dorothee, McAndrew, Debra J, Zervou, Sevasti, Whittington, Hannah J, Simon, Jillian N, Aksentijevic, Dunja, ten Hove, Michiel, Choe, Chi-un, Isbrandt, Dirk, Casadei, Barbara, Schneider, Jurgen E, Neubauer, Stefan, Lygate, Craig A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5982714/
https://ncbi.nlm.nih.gov/pubmed/29236952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvx242
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