Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

Many proteins are refractory to targeting because they lack small-molecule binding pockets. An alternative to drugging these proteins directly is to target the messenger (m)RNA that encodes them, thereby reducing protein levels. We describe such an approach for the difficult-to-target protein α-synu...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Zhang, Peiyuan, Park, Hye-Jin, Zhang, Jie, Junn, Eunsung, Andrews, Ryan J., Velagapudi, Sai Pradeep, Abegg, Daniel, Vishnu, Kamalakannan, Costales, Matthew G., Childs-Disney, Jessica L., Adibekian, Alexander, Moss, Walter N., Mouradian, M. Maral, Disney, Matthew D.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983430/
https://ncbi.nlm.nih.gov/pubmed/31900363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905057117
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