Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

Many proteins are refractory to targeting because they lack small-molecule binding pockets. An alternative to drugging these proteins directly is to target the messenger (m)RNA that encodes them, thereby reducing protein levels. We describe such an approach for the difficult-to-target protein α-synu...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhang, Peiyuan, Park, Hye-Jin, Zhang, Jie, Junn, Eunsung, Andrews, Ryan J., Velagapudi, Sai Pradeep, Abegg, Daniel, Vishnu, Kamalakannan, Costales, Matthew G., Childs-Disney, Jessica L., Adibekian, Alexander, Moss, Walter N., Mouradian, M. Maral, Disney, Matthew D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983430/
https://ncbi.nlm.nih.gov/pubmed/31900363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905057117
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