Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

Many proteins are refractory to targeting because they lack small-molecule binding pockets. An alternative to drugging these proteins directly is to target the messenger (m)RNA that encodes them, thereby reducing protein levels. We describe such an approach for the difficult-to-target protein α-synu...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Zhang, Peiyuan, Park, Hye-Jin, Zhang, Jie, Junn, Eunsung, Andrews, Ryan J., Velagapudi, Sai Pradeep, Abegg, Daniel, Vishnu, Kamalakannan, Costales, Matthew G., Childs-Disney, Jessica L., Adibekian, Alexander, Moss, Walter N., Mouradian, M. Maral, Disney, Matthew D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983430/
https://ncbi.nlm.nih.gov/pubmed/31900363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905057117
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