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Discovery of an Orally Effective Factor IX-Transferrin Fusion Protein for Hemophilia B
Hemophilia B is a severe blood clotting disorder caused by the deficiency of factor IX (FIX). FIX is not bioavailable when given orally due to poor stability and permeability in the gastrointestinal tract. The feasibility of fusing FIX with transferrin (Tf) to enhance the oral bioavailability of FIX...
Guardat en:
| Publicat a: | Int J Mol Sci |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6981973/ https://ncbi.nlm.nih.gov/pubmed/31861459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21010021 |
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