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Discovery of an Orally Effective Factor IX-Transferrin Fusion Protein for Hemophilia B
Hemophilia B is a severe blood clotting disorder caused by the deficiency of factor IX (FIX). FIX is not bioavailable when given orally due to poor stability and permeability in the gastrointestinal tract. The feasibility of fusing FIX with transferrin (Tf) to enhance the oral bioavailability of FIX...
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| Publicado no: | Int J Mol Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6981973/ https://ncbi.nlm.nih.gov/pubmed/31861459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21010021 |
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