Low cost industrial production of coagulation factor IX bioencapsulated in lettuce cells for oral tolerance induction in hemophilia B

Antibodies (inhibitors) developed by hemophilia B patients against coagulation factor IX (FIX) are challenging to eliminate because of anaphylaxis or nephrotic syndrome after continued infusion. To address this urgent unmet medical need, FIX fused with a transmucosal carrier (CTB) was produced in a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Biomaterials
Egile Nagusiak: Su, Jin, Zhu, Liqing, Sherman, Alexandra, Wang, Xiaomei, Lin, Shina, Kamesh, Aditya, Norikane, Joey H., Streatfield, Stephen J., Herzog, Roland W., Daniell, Henry
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562874/
https://ncbi.nlm.nih.gov/pubmed/26302233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.08.004
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